Order Phentermine 37.5mg Without Prescription

  Uses of Phentermine 

Phentermine is used orally to improve wakefulness in adults with excessive sleepiness associated with narcolepsy, obstructive sleep apnea/hypopnea syndrome (OSAHS), and shift work sleep disorder (SWSD). Careful attention to the diagnosis and treatment of the underlying sleep disorder is essential whenever Phentermine is used in patients with these conditions.(See Diagnosis of Sleep Disorders under Warnings/Precautions: General Precautions, in Cautions.)

Narcolepsy

Buy Phentermine 37.5mg Without Prescription is used in the symptomatic treatment of narcolepsy to improve wakefulness in adults with excessive daytime sleepiness (EDS). Narcolepsy is a CNS disorder characterized by somnolence, often accompanied by sudden attacks of weakness (cataplexy) while awake and disrupted nocturnal sleep, and occasionally by hypnagogic hallucinations and/or sleep paralysis before falling asleep or awakening. The disorder involves dysregulation of wakefulness and sleep.

Efficacy of Phentermine has been established in the US in 2 double-blind, multicenter, placebo-controlled clinical trials of 9 weeks' duration. In these and other clinical studies, modafinil 200 or 400 mg daily increased daytime wakefulness and alertness and decreased the number of daytime sleep episodes as determined by several objective (e.g., the Multiple Sleep Latency Test [MSLT], the Maintenance of Wakefulness Test [MWT], the Steer Clear Performance Test [SCPT]) and subjective (e.g., the Epworth Sleepiness Scale [ESS]) measures of sleepiness. Patients showed an enhanced ability to remain awake with both dosages relative to placebo at 3, 6, and 9 weeks, and at study end point (last post-baseline assessment while the patient was in the study) and also greater global improvement in overall disease status (measured by the Clinical Global Impression of Change [CGI-C]). However, despite the clinical improvement, mean objective and subjective measures of sleepiness did not completely normalize with Phentermine therapy, with a degree of clinically important physiologic sleepiness persisting despite therapy. The percentage of patients exhibiting any degree of improvement in overall disease status on the CGI-C in the two 9-week studies establishing efficacy in the US was 60-72, 58-64, or 37-38% for the 400-mg regimen, 200-mg regimen, or placebo, respectively. The efficacy of the 2 Phentermine dosage regimens was not shown to differ significantly in these studies.

Although the long-term efficacy of modafinil has not been established systematically beyond 9 weeks, improvements in overall disease status on the CGI-C and in subjective measures of sleepiness on the ESS were maintained in a 40-week open-label extension of one of the trials. In this open-label extension, the percentage of patients exhibiting improvement on the CGI-C ranged from 84% after 2 weeks of extension therapy to 91% after 40 weeks. The drug also was well tolerated for up to 40 weeks of therapy, with 11% of patients discontinuing Phentermine because of adverse effects and 14% because of inadequate therapeutic effect. Although most patients enrolled in the 2 clinical trials establishing efficacy in the US had histories of cataplexy, those requiring anticataplectic therapy generally were excluded from enrollment. Therefore, current evidence of efficacy for Phentermine is limited principally to effects on excessive daytime sleepiness. In one study in a limited number of patients, cataplexy was not affected by modafinil therapy.

Order Phentermine 37.5mg Without Prescription did not affect the initiation, maintenance, quality, or quantity of nighttime sleep and did not affect the ability to voluntarily sleep (nap) during the daytime. Like other CNS stimulants Phentermine can alter mood, perception, thinking, and feelings and can cause psychoactive and euphoric effects. However, in clinical trials, there was no clinically important association between Phentermine and the incidence of agitation in patients. In animals, modafinil is reinforcing; however, the somatic effects of the drug were comparable to those of caffeine and differed from those of amphetamine. Although current evidence indicates that the risk of abuse or misuse of modafinil is lower than that associated with some other CNS stimulants (e.g., amphetamines, methylphenidate), caution is recommended in patients with a history of drug or stimulant abuse. Withdrawal of modafinil has not been associated with any manifestations of dependency.